MLS000532223|cas:16616-39-0|西域试剂

MLS000532223,99.46%

产品编号：Bellancom-117149| CAS NO：16616-39-0| 分子式：C₁₅H₉NO₃| 分子量：251.24

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货号	价格	库存与货期
Bellancom-117149	￥3000.00	杭州北京（现货）
Bellancom-117149	￥4500.00	杭州北京（现货）
Bellancom-117149	￥14000.00	杭州北京（现货）

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MLS000532223

产品介绍

MLS000532223 是一种选择性的，具有高亲和力的 Rho 家族 GTPases (Rho family GTPases) 抑制剂，其 EC₅₀ 值的范围为 16-120 μM。MLS000532223 能阻止 GTP 与几种 GTPases 相结合。

生物活性

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC₅₀ values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases.

体外研究

MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner.
MLS000532223 modulates Rho-family GTP-binding kinetics.
MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation.
MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation.
MLS000532223 (10 μM) modulates actin remodeling in mast cells.
MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (199.01 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9803 mL	19.9013 mL	39.8026 mL
5 mM	0.7961 mL	3.9803 mL	7.9605 mL
10 mM	0.3980 mL	1.9901 mL	3.9803 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式