TP-020 MGAT2-IN-1|cas:1800025-30-2|西域试剂

TP-020 MGAT2-IN-1,98.96%

产品编号：Bellancom-101857| CAS NO：1800025-30-2| 分子式：C₂₇H₂₁ClF₅N₇O₃S| 分子量：654.01

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货号	价格	库存与货期
Bellancom-101857	￥4500.00	杭州北京（现货）
Bellancom-101857	￥7500.00	杭州北京（现货）
Bellancom-101857	￥15000.00	杭州北京（现货）
Bellancom-101857	￥22000.00	杭州北京（现货）
Bellancom-101857	￥35000.00	杭州北京（现货）

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TP-020 MGAT2-IN-1

产品介绍

TP-020 (MGAT2-IN-1) 是一种可口服的单酰甘油酰基转移酶 (MGAT2) 抑制剂，对人和小鼠 MGAT2 的 IC₅₀ 值分别为 7.8 和 2.4 nM。

生物活性

TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC₅₀ of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

体外研究

体内研究

TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. TP-020 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, TP-020 significantly increases free fatty acid (FFA) and acylcarnitine levels. TP-020 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. TP-020 shows anti-diabetic effects in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 125 mg/mL (191.13 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5290 mL	7.6451 mL	15.2903 mL
5 mM	0.3058 mL	1.5290 mL	3.0581 mL
10 mM	0.1529 mL	0.7645 mL	1.5290 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式