Beinaglutide GLP-1 (human)|cas:123475-27-4|西域试剂

Beinaglutide GLP-1 (human),99.47%

产品编号：Bellancom-P3463| CAS NO：123475-27-4| 分子式：C₁₄₉H₂₂₅N₃₉O₄₆| 分子量：3298.61

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货号	价格	库存与货期
Bellancom-P3463	￥1600.00	杭州北京（现货）
Bellancom-P3463	￥3600.00	杭州北京（现货）
Bellancom-P3463	￥5800.00	杭州北京（现货）

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Beinaglutide GLP-1 (human)

产品介绍

Beinaglutide 是一种重组人 GLP-1 (rhGLP-1) 多肽，与人 GLP-1(7-36) 具有几乎 100% 的同源性。Beinaglutide 在血糖控制、抑制食物摄入和胃排空和促进体重减轻方面表现出依赖于剂量的作用。Beinaglutide 具有研究超重/肥胖和非酒精性脂肪性肝炎 (NASH) 的潜力。

生物活性

Beinaglutide is a recombinant human GLP-1 (rhGLP-1) polypeptide that shares almost 100% homology with human GLP-1 (7–36). Beinaglutide displays does-dependent effects in glycemic control, inhibiting food intake and gastric empty and promoting weight loss. Beinaglutide has the potential for the research of overweight/obesity and nonalcoholic steatohepatitis (NASH).

体外研究

Beinaglutide (100 nM; 48 h) increases the expression of phosphorylation of Akt in the adipocytes that were potentiated insulin-stimulated.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	3T3L-1 cells
Concentration:	100 nM
Incubation Time:	48 h
Result:	Increased the phosphorylation of Akt in the adipocytes that were potentiated insulin-stimulated.

体内研究
(In Vivo)

Beinaglutide (0.6, 1.2, 2.4 mg/kg; s.c.; three times per day for 7 consecutive days) shows the ability of glycemic contro, inhibits food intake and weight loss in mouse.
Beinaglutide (150 µg/kg; s.c.; daily for 6 weeks) increases insulin sensitivity of adipocytes.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild-type male C57BL/6 mice and Male Lepob/Lepob (ob/ob) mice (ob/ob-NASH mouse model was induced by GAN diet)
Dosage:	0.6, 1.2, 2.4 mg/kg
Administration:	S.c.; three times per day for 7 consecutive days
Result:	Significantly reduced blood glucose with dosedependence in C57BL/6 and ob/ob mice, dose dependently inhibits food intake and gastric Emptying, and significantly reduced body weight, food intake with dose-dependence.

Animal Model:	Eight-week-old male C57BL/6 mice
Dosage:	150 µg/kg
Administration:	S.c.; daily for 6 weeks
Result:	Showed improved glucose tolerance and insulin sensitivity, decreased adipose tissue weight and adipocyte size and potentiated insulin sensitivity of adipocytes.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild-type male C57BL/6 mice and Male Lepob/Lepob (ob/ob) mice (ob/ob-NASH mouse model was induced by GAN diet)
Dosage:	0.6, 1.2, 2.4 mg/kg
Administration:	S.c.; three times per day for 7 consecutive days
Result:	Significantly reduced blood glucose with dosedependence in C57BL/6 and ob/ob mice, dose dependently inhibits food intake and gastric Emptying, and significantly reduced body weight, food intake with dose-dependence.

Animal Model:	Eight-week-old male C57BL/6 mice
Dosage:	150 µg/kg
Administration:	S.c.; daily for 6 weeks
Result:	Showed improved glucose tolerance and insulin sensitivity, decreased adipose tissue weight and adipocyte size and potentiated insulin sensitivity of adipocytes.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild-type male C57BL/6 mice and Male Lepob/Lepob (ob/ob) mice (ob/ob-NASH mouse model was induced by GAN diet)
Dosage:	0.6, 1.2, 2.4 mg/kg
Administration:	S.c.; three times per day for 7 consecutive days
Result:	Significantly reduced blood glucose with dosedependence in C57BL/6 and ob/ob mice, dose dependently inhibits food intake and gastric Emptying, and significantly reduced body weight, food intake with dose-dependence.

Animal Model:	Eight-week-old male C57BL/6 mice
Dosage:	150 µg/kg
Administration:	S.c.; daily for 6 weeks
Result:	Showed improved glucose tolerance and insulin sensitivity, decreased adipose tissue weight and adipocyte size and potentiated insulin sensitivity of adipocytes.