VU0119498|cas:79183-37-2|西域试剂

VU0119498,99.52%

产品编号：Bellancom-114933| CAS NO：79183-37-2| 分子式：C₁₅H₁₀BrNO₂| 分子量：316.15

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货号	价格	库存与货期
Bellancom-114933	￥600.00	杭州北京（现货）
Bellancom-114933	￥1100.00	杭州北京（现货）
Bellancom-114933	￥1600.00	杭州北京（现货）
Bellancom-114933	￥2400.00	杭州北京（现货）

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VU0119498

产品介绍

VU0119498 是一种泛 G_q mAChR M1，M3，M5 的正变构调节剂 (PAM)，EC₅₀ 值分别为 6.04，6.38 和 4.08 µM。VU0119498 具有抗糖尿病活性。

生物活性

VU0119498 is a pan G_q mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC₅₀s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity.

体外研究

VU0119498 (0.01-30 μM; 150 s) potentiates Ach responses in M1, M3, and M5-expressing CHO cells, with EC₅₀s of 6.04, 6.38, and 4.08 µM, respectively.
VU0119498 (3-20 μM) augments ACh-mediated increasing in insulin secretion and intracellular calcium levels in MIN6-K8 cells.
VU0119498 (20 μM; 90 min) enhances ACh-induced insulin release in mouse and human pancreatic islets.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion.
VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male WT mice (12 weeks)
Dosage:	0.1, 0.5, 2 mg/kg
Administration:	A single i.p.
Result:	Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg. Significantly augmented GSIS at the dose of 0.5 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male WT mice (12 weeks)
Dosage:	0.1, 0.5, 2 mg/kg
Administration:	A single i.p.
Result:	Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg. Significantly augmented GSIS at the dose of 0.5 mg/kg.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (158.15 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1631 mL	15.8153 mL	31.6306 mL
5 mM	0.6326 mL	3.1631 mL	6.3261 mL
10 mM	0.3163 mL	1.5815 mL	3.1631 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式