Neticonazole hydrochloride|cas:130773-02-3|西域试剂

Neticonazole hydrochloride,99.71%

产品编号：Bellancom-128365| CAS NO：130773-02-3| 分子式：C₁₇H₂₃ClN₂OS| 分子量：338.90

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货号	价格	库存与货期
Bellancom-128365	￥650.00	杭州北京（现货）
Bellancom-128365	￥950.00	杭州北京（现货）
Bellancom-128365	￥1600.00	杭州北京（现货）

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Neticonazole hydrochloride

产品介绍

Neticonazole hydrochloride 是一种咪唑衍生物，也是一种有效且长效的抗真菌剂。Neticonazole hydrochloride 具有抗感染和抗癌作用。

生物活性

Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects.

体外研究

Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	C4-2B cells
Concentration:	10 µM
Incubation Time:	48 hours
Result:	Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.

体内研究
(In Vivo)

Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage:	1 ng/kg, 10 ng/kg and 100 ng/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Significantly improved the survival of IDB mice with CRC xenograft tumors.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage:	1 ng/kg, 10 ng/kg and 100 ng/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Significantly improved the survival of IDB mice with CRC xenograft tumors.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage:	1 ng/kg, 10 ng/kg and 100 ng/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Significantly improved the survival of IDB mice with CRC xenograft tumors.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (737.68 mM; Need ultrasonic)

H₂O : ≥ 100 mg/mL (295.07 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9507 mL	14.7536 mL	29.5072 mL
5 mM	0.5901 mL	2.9507 mL	5.9014 mL
10 mM	0.2951 mL	1.4754 mL	2.9507 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (295.07 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 6.25 mg/mL (18.44 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (18.44 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 6.25 mg/mL (18.44 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (18.44 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 6.25 mg/mL (18.44 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (18.44 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。