AMG7703|cas:1103523-24-5|西域试剂

AMG7703,99.24%

产品编号：Bellancom-114011| CAS NO：1103523-24-5| 分子式：C₁₄H₁₅ClN₂OS| 分子量：294.80

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货号	价格	库存与货期
Bellancom-114011	￥1620.00	杭州北京（现货）
Bellancom-114011	￥2520.00	杭州北京（现货）
Bellancom-114011	￥4680.00	杭州北京（现货）
Bellancom-114011	￥7200.00	杭州北京（现货）
Bellancom-114011	￥10800.00	杭州北京（现货）

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AMG7703

产品介绍

AMG7703 是一种 FFA2 (GPR43) 的选择性变构激动剂，FFA2 是短链脂肪酸 (SCFA)、醋酸盐 (acetate) 和丙酸 (methylacetic) 的受体。AMG7703可用于炎症和代谢的研究。

生物活性

AMG7703 is a selective and allosteric agonists of FFA2 (GPR43), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic.

体外研究

AMG7703 (phenylacetamide 1) (30 μM) shows selectivity on FFA2 (GPR43) over FFA1 (GPR40) and FFA3 (GPR41) with in Chinese hamster ovary cells.
AMG7703 (0.041, 0.123, 0.37, 1.11 μM) acts as an FFA2 allosteric agonist, activates Gα_i coupled signaling pathway.
AMG7703 (1, 3, 10, 30 μM) results in Gα_i-dependent inhibition of lipolysis in adipocytes (3T3L1).
AMG7703 (0.041, 0.123, 0.37, 1.11 μM) exhibits allosteric activity and inhibits Gα_i-coupled cAMP with IC₅₀ values of 0.7 μM (hFFA2) and 0.96 μM (mFFA2), respectively; as for Gα_q-coupled aequorin inhibition, with EC₅₀s of 0.45 μM (hFFA2) and 1.27 μM (mFFA2), respectively.
AMG7703 (0-1 μM) shows the positive cooperating effect of acetate and stimulates calcium mobilization in a concentration-dependent manner in CHO cell stably expressing hFFA2 and aequorin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (339.21 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3921 mL	16.9607 mL	33.9213 mL
5 mM	0.6784 mL	3.3921 mL	6.7843 mL
10 mM	0.3392 mL	1.6961 mL	3.3921 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式