YIL781 hydrochloride|cas:1640226-17-0|西域试剂

YIL781 hydrochloride,99.0%

产品编号：Bellancom-13964A| CAS NO：1640226-17-0| 分子式：C₂₄H₂₉ClFN₃O₂| 分子量：445.96

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-13964A		￥950.00	杭州北京（现货）
Bellancom-13964A		￥2800.00	杭州北京（现货）

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YIL781 hydrochloride

产品介绍

YIL781 hydrochloride 是有效的、具有口服活性的胃促生长素受体 (GHSR) 的拮抗剂。YIL781 hydrochloride 可改善大鼠体内葡萄糖稳态。YIL781 hydrochloride 可抑制饥饿素诱导的钙反应，pIC₅₀ 值分别为 7.90 和 8.27。

生物活性

YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL-781 hydrochloride inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively^[4].

体外研究

YIL-781 (10-300 nM) induces a concentration-dependent parallel rightward shift of the ghrelin CRC with a slight but statistically significant depression of the maximal response at 100 and 300 nM, reaching a similar agonist maximal response of approximately 90%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

YIL781 (0.1 to 5 μg/5 μl) attenuates ghrelin-induced up-regulation of the blood glucose level. The i.t. treatment with YIL781 alone does not affect the blood glucose level (F = 0.8160; P = 0.5095)^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious mice^[4].
Dosage:	0.1 to 5 μg/5 μl.
Administration:	Intrathecal (i.t.) injection.
Result:	Attenuated ghrelin-induced up-regulation of the blood glucose level (F = 0.7506; P = 0.5729) (YIL781 5 g + ghrelin 5 g −9.1% at 30 min; −14.9% at 60 min). The i.t. treatment with YIL781 alone did not affect the blood glucose level (F = 0.8160; P = 0.5095).

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious mice^[4].
Dosage:	0.1 to 5 μg/5 μl.
Administration:	Intrathecal (i.t.) injection.
Result:	Attenuated ghrelin-induced up-regulation of the blood glucose level (F = 0.7506; P = 0.5729) (YIL781 5 g + ghrelin 5 g −9.1% at 30 min; −14.9% at 60 min). The i.t. treatment with YIL781 alone did not affect the blood glucose level (F = 0.8160; P = 0.5095).