S-23|cas:1010396-29-8|西域试剂

S-23,99.95%

产品编号：Bellancom-112257| CAS NO：1010396-29-8| 分子式：C₁₈H₁₃ClF₄N₂O₃| 分子量：416.75

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货号	价格	库存与货期
Bellancom-112257	￥500.00	杭州北京（现货）
Bellancom-112257	￥800.00	杭州北京（现货）
Bellancom-112257	￥1600.00	杭州北京（现货）
Bellancom-112257	￥2500.00	杭州北京（现货）
Bellancom-112257	￥3900.00	杭州北京（现货）

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S-23

产品介绍

S-23 是一种口服选择性雄激素受体调节剂 (SARM)，K_i 为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。

生物活性

S-23 is an orally active selective androgen receptor modulator (SARM) with a K_i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

体外研究

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED₅₀ of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (in castrated male rats)
Dosage:	0.01-3 mg
Administration:	S.c.; daily for 14 d
Result:	Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (in castrated male rats)
Dosage:	0.01-3 mg
Administration:	S.c.; daily for 14 d
Result:	Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (239.95 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3995 mL	11.9976 mL	23.9952 mL
5 mM	0.4799 mL	2.3995 mL	4.7990 mL
10 mM	0.2400 mL	1.1998 mL	2.3995 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式