CBR-470-2|cas:2416095-00-4|西域试剂

CBR-470-2,99.22%

产品编号：Bellancom-134001| CAS NO：2416095-00-4| 分子式：C₁₂H₁₃Cl₂NO₆S₂| 分子量：402.27

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-134001	￥4800.00	杭州北京（现货）
Bellancom-134001	￥8000.00	杭州北京（现货）
Bellancom-134001	￥15500.00	杭州北京（现货）
Bellancom-134001	￥24000.00	杭州北京（现货）
Bellancom-134001	￥35000.00	杭州北京（现货）

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CBR-470-2

产品介绍

CBR-470-2 是甘氨酸取代的类似物，可以激活 NRF2 信号传导。CBR-470-2 可用于调节糖酵解。

生物活性

CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis.

体外研究

CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/C mice (5-week old) are exposed to UVB
Dosage:	50 mg/kg
Administration:	P.o. twice daily for 10 days
Result:	Resulted in comparable beneficial effects on erythema histological scores and total wounded area. Decreased epidermal thickness in response to UV exposure.

体内研究

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/C mice (5-week old) are exposed to UVB
Dosage:	50 mg/kg
Administration:	P.o. twice daily for 10 days
Result:	Resulted in comparable beneficial effects on erythema histological scores and total wounded area. Decreased epidermal thickness in response to UV exposure.

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (497.18 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4859 mL	12.4295 mL	24.8589 mL
5 mM	0.4972 mL	2.4859 mL	4.9718 mL
10 mM	0.2486 mL	1.2429 mL	2.4859 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 5 mg/mL (12.43 mM); Clear solution

此方案可获得 ≥ 5 mg/mL (12.43 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。