L-Phenylalanine-d<sub>5</sub> L-苯丙氨酸-d<sub>5</sub>|cas:56253-90-8|西域试剂

L-Phenylalanine-d₅ L-苯丙氨酸-d₅,99.15%

产品编号：Bellancom-N0215S12| CAS NO：56253-90-8| 分子式：C₉H₆D₅NO₂| 分子量：170.22

L-苯丙氨酸d5是氘标记的L-苯丙氨酸。L-苯丙氨酸（（S）-2-氨基-3-苯丙酸）是从大肠杆菌中分离出来的一种必需氨基酸。L-苯丙氨酸是电压依赖性钙通道拮抗剂的α2δ亚单位，Ki为980 nM。L-苯丙氨酸是N-甲基-D-天冬氨酸受体（NMDARs）（KB为573μM）和非NMDARs的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-苯丙氨酸广泛用于食品香精和药品的生产。

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货号	价格	库存与货期
Bellancom-N0215S12	￥500.00	杭州北京（现货）
Bellancom-N0215S12	￥800.00	杭州北京（现货）
Bellancom-N0215S12	￥2200.00	杭州北京（现货）
Bellancom-N0215S12	￥3500.00	杭州北京（现货）

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L-Phenylalanine-d₅ L-苯丙氨酸-d₅

产品介绍

L-Phenylalanine-d₅ 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2⁺ 通道拮抗剂，K_i 为 980 nM。L-Phenylalanine 是 NMDARs (K_B 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。

生物活性

L-Phenylalanine-d₅ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[4].

体外研究

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 12.5 mg/mL (73.43 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.8748 mL	29.3738 mL	58.7475 mL
5 mM	1.1750 mL	5.8748 mL	11.7495 mL
10 mM	0.5875 mL	2.9374 mL	5.8748 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献

. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

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L-Phenylalanine-d5 L-苯丙氨酸-d5,99.15%

L-Phenylalanine-d5 L-苯丙氨酸-d5

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L-Phenylalanine-d₅ L-苯丙氨酸-d₅,99.15%

L-Phenylalanine-d₅ L-苯丙氨酸-d₅