LKY-047|cas:1954681-29-8|西域试剂

LKY-047,98.85%

产品编号：Bellancom-117026| CAS NO：1954681-29-8| 分子式：C₂₃H₁₉NO₇| 分子量：421.40

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-117026		￥7500.00	杭州北京（现货）
Bellancom-117026		￥12000.00	杭州北京（现货）

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LKY-047

产品介绍

LKY-047，是 Decursin 的一种衍生物，是一种有效的选择性的可逆竞争性的细胞色素 P45022J2 (CYP2J2) 抑制剂，IC₅₀ 为 1.7 μM。LKY-047 对其他人类 P450 无效，例如 CYP1A2、CYP2A6、CYP2B6、CYP2C8、CYP2C9、CYP2C19、CYP2D6、CYP2E1 和 CYP3A。

生物活性

LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC₅₀ of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A.

体外研究

LKY-047 is a strong competitive inhibitor of CYP2J2-mediated astemizole O-demethylase and terfenadine hydroxylase activity, with K_i values of 0.96 μM and 2.61 μM, respectively. LKY-047 also acted as an uncompetitive inhibitor of CYP2J2-mediated ebastine hydroxylation with a K_i value of 3.61 μM.
At 20 μM LKY-047 concentration, approximately 20-fold greater than the Ki value, LKY-047 is found to inhibit CYP2J2 by 85.3%, and only slightly affecting the enzyme activities of the other P450s tested. LKY-047 weakly inhibits CYP2D6 enzyme activity (37.2%) at 20 μM concentration.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 16.67 mg/mL (39.56 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3730 mL	11.8652 mL	23.7304 mL
5 mM	0.4746 mL	2.3730 mL	4.7461 mL
10 mM	0.2373 mL	1.1865 mL	2.3730 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式