Maralixibat chloride SHP625 chloride; LUM001 chloride; Lopixibat chloride|cas:228113-66-4|西域试剂

Maralixibat chloride SHP625 chloride; LUM001 chloride; Lopixibat chloride,99.08%

产品编号：Bellancom-16747| CAS NO：228113-66-4| 分子式：C₄₀H₅₆ClN₃O₄S| 分子量：710.41

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-16747		￥22000.00	杭州北京（现货）

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Maralixibat chloride SHP625 chloride; LUM001 chloride; Lopixibat chloride

产品介绍

Maralixibat (SHP625) chloride 是一种口服活性回肠胆汁酸转运体 (IBAT) 抑制剂。(IBAT) 可用于研究罕见的胆汁淤积性肝病，包括 Alagille 综合征 (ALGS)、进行性家族性肝内胆汁淤积症 (PFIC) 和胆道闭锁。

生物活性

Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia.

体外研究

体内研究

Maralixibat chloride reduces elevations in sBA levels, improves liver function, and reduces liver tissue damage, in a rat partial bile duct ligation model of cholestasis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Maralixibat chloride reduces elevations in sBA levels, improves liver function, and reduces liver tissue damage, in a rat partial bile duct ligation model of cholestasis.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (70.38 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4076 mL	7.0382 mL	14.0764 mL
5 mM	0.2815 mL	1.4076 mL	2.8153 mL
10 mM	0.1408 mL	0.7038 mL	1.4076 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献