NCGC00247743|cas:1435192-04-3|西域试剂

NCGC00247743,98.61%

产品编号：Bellancom-112308| CAS NO：1435192-04-3| 分子式：C₂₄H₂₉N₃O₂| 分子量：391.51

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货号	价格	库存与货期
Bellancom-112308	￥5500.00	杭州北京（现货）
Bellancom-112308	￥8500.00	杭州北京（现货）
Bellancom-112308	￥16000.00	杭州北京（现货）

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NCGC00247743

产品介绍

NCGC00247743 是一种组蛋白赖氨酸脱甲基酶 KDM4 抑制剂。

生物活性

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

体外研究

Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC₅₀s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (159.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5542 mL	12.7711 mL	25.5421 mL
5 mM	0.5108 mL	2.5542 mL	5.1084 mL
10 mM	0.2554 mL	1.2771 mL	2.5542 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式