TEI-9648|cas:173388-21-1|西域试剂

TEI-9648,98.67%

产品编号：Bellancom-12398A| CAS NO：173388-21-1| 分子式：C₂₇H₃₈O₄| 分子量：426.59

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货号	价格	库存与货期
Bellancom-12398A	￥5500.00	杭州北京（现货）
Bellancom-12398A	￥17500.00	杭州北京（现货）
Bellancom-12398A	￥28500.00	杭州北京（现货）

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TEI-9648

产品介绍

TEI-9648 是一种 Vitamin D₃ Lactone 类似物，是有效的，特异性的维生素 D 受体 (VDR) 拮抗剂。TEI-9648 抑制 VDR/VDRE 介导的 1α,25(OH)₂D₃ 的基因组作用。TEI-9648 也可以抑制 1α,25(OH)₂D₃ 诱导的 HL-60 细胞分化。TEI-9648 有潜力用于骨代谢的研究。

生物活性

TEI-9648, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9648 has the potential for bone metabolism research.

体外研究

TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)₂D₃.
TEI-9648 has consistently weaker suppressive effect than TEI-9647.
TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell.
TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)₂D₃ (0.1 nM) in HL-60 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (117.21 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3442 mL	11.7209 mL	23.4417 mL
5 mM	0.4688 mL	2.3442 mL	4.6883 mL
10 mM	0.2344 mL	1.1721 mL	2.3442 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献