(S,R,S)-AHPC-PEG2-C4-Cl VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10|cas:1835705-57-1|西域试剂

(S,R,S)-AHPC-PEG2-C4-Cl VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10,98.12%

产品编号：Bellancom-103607| CAS NO：1835705-57-1| 分子式：C₃₂H₄₇ClN₄O₆S| 分子量：651.26

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货号	价格	库存与货期
Bellancom-103607	￥3500.00	杭州北京（现货）
Bellancom-103607	￥13500.00	杭州北京（现货）
Bellancom-103607	￥25000.00	杭州北京（现货）
Bellancom-103607	￥35000.00	杭州北京（现货）

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(S,R,S)-AHPC-PEG2-C4-Cl VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10

产品介绍

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) 由 E3 配体与 13 个原子相连的复合分子，连接子的接头为 Halogen 基团。(S,R,S)-AHPC-PEG2-C4-Cl 包含基于 (S,R,S)-AHPC 的 VHL 配体和 alkyl/ether linker。(S,R,S)-AHPC-PEG2-C4-Cl 能够诱导 GFP-HaloTag7 降解。

生物活性

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

体外研究

(S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Oil

溶解性数据

In Vitro:

DMSO : ≥ 50 mg/mL (76.77 mM)

Ethanol : 50 mg/mL (76.77 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5355 mL	7.6774 mL	15.3548 mL
5 mM	0.3071 mL	1.5355 mL	3.0710 mL
10 mM	0.1535 mL	0.7677 mL	1.5355 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式