GPR40 agonist 6|cas:1798751-25-3|西域试剂

GPR40 agonist 6,99.64%

产品编号：Bellancom-147351| CAS NO：1798751-25-3| 分子式：C₂₀H₁₉NO₄| 分子量：337.37

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货号	价格	库存与货期
Bellancom-147351	￥1200.00	杭州北京（现货）
Bellancom-147351	￥1900.00	杭州北京（现货）
Bellancom-147351	￥3800.00	杭州北京（现货）
Bellancom-147351	￥6200.00	杭州北京（现货）
Bellancom-147351	￥9800.00	杭州北京（现货）

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GPR40 agonist 6

产品介绍

GPR40 agonist 6 (Compound 7a) 是一种有效的、选择性的游离脂肪酸受体 1 (FFAR1 或 GPR40) 激动剂，EC₅₀ 为 0.058 μM。

生物活性

GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC₅₀ of 0.058 μM.

体外研究

GPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 µM.
ADME profile for GPR40 agonist 6 (Compound 7a)

	GPR40 agonist 6 (Compound 7a)
Plasma protein binding (human)^a	98.6%
Aqueous solubility (PBS, pH 7.4)^b	404 µM
Microsomal stability (mouse, t1/2)^c	434 min
A-B permeability (Caco-2, cm•s^-1)^d	15.2 • 10^-6

^aEach value is an average of n = 4, measured at c = 1 µM.
^bEach value is an average of n = 2.
^cEach value is an average of n = 5, measured at c = 2 µM.
^dEach value is an average of n = 2, measured at c = 10 µM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (370.51 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9641 mL	14.8205 mL	29.6410 mL
5 mM	0.5928 mL	2.9641 mL	5.9282 mL
10 mM	0.2964 mL	1.4821 mL	2.9641 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式