IGF-I (24-41) Insulin-like Growth Factor I (24-41)|cas:135861-49-3|西域试剂

IGF-I (24-41) Insulin-like Growth Factor I (24-41),99.83%

产品编号：Bellancom-P1777| CAS NO：135861-49-3| 分子式：C₈₈H₁₃₃N₂₇O₂₈| 分子量：2017.16

IGF-I (24-41) 是类胰岛素生长因子I 24 至 41 的氨基酸片段。IGF-I 对生长激素的活性有着重要的作用，但是IGF-I本身也具有一些自身的特性，如合成代谢、抗氧化、抗炎和细胞保护作用。

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货号	价格	库存与货期
Bellancom-P1777	￥2500.00	杭州北京（现货）
Bellancom-P1777	￥6000.00	杭州北京（现货）
Bellancom-P1777	￥10000.00	杭州北京（现货）

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IGF-I (24-41) Insulin-like Growth Factor I (24-41)

产品介绍

IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) 是类胰岛素生长因子 I 24 至 41 的氨基酸片段。IGF-I 是一种 70 个氨基酸的多肽激素，是神经元和神经胶质细胞的营养因子。IGF-I对全身生长激素 (GH) 的活动有重要的作用。IGF-I 具有合成代谢、抗氧化、抗炎和细胞保护作用。IGF-I (24-41) 可以调节躯体生长和行为发育。

生物活性

IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development.

体外研究

体内研究

IGF-I (24-41) (ICV; 200 ng dose; 2 µL; postnatal days 2, 4, and 7) regulates somatic growth and behavioral development.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)
Dosage:	200 ng dose; 2 µL
Administration:	ICV; postnatal days (PND) 2, 4, and 7
Result:	Increased the rate of ultrasonic calls of the pups measured on PND8.

体内研究

IGF-I (24-41) (ICV; 200 ng dose; 2 µL; postnatal days 2, 4, and 7) regulates somatic growth and behavioral development.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)
Dosage:	200 ng dose; 2 µL
Administration:	ICV; postnatal days (PND) 2, 4, and 7
Result:	Increased the rate of ultrasonic calls of the pups measured on PND8.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (24.79 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.4957 mL	2.4787 mL	4.9575 mL
5 mM	0.0991 mL	0.4957 mL	0.9915 mL
10 mM	0.0496 mL	0.2479 mL	0.4957 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (49.57 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Puche JE, et al. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. [Content Brief]

. D Santucci, et al. IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull. 1994;35(4):367-71. [Content Brief]

. Dan Meng, et al. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med. 2007 Jun 1;42(11):1651-60. [Content Brief]

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产品编号(Item Number)

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IGF-I (24-41) Insulin-like Growth Factor I (24-41),99.83%

IGF-I (24-41) Insulin-like Growth Factor I (24-41)

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