P053|cas:2748196-63-4|西域试剂

P053,97.0%

产品编号：Bellancom-126015| CAS NO：2748196-63-4| 分子式：C₁₈H₂₁Cl₂NO₂| 分子量：354.27

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-126015	￥5000.00	杭州北京（现货）
Bellancom-126015	￥8500.00	杭州北京（现货）
Bellancom-126015	￥18000.00	杭州北京（现货）
Bellancom-126015	￥30000.00	杭州北京（现货）
Bellancom-126015	￥46000.00	杭州北京（现货）

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P053

产品介绍

P053 是一种有效的，非竞争性和选择性的神经酰胺合酶1 (CerS1) 抑制剂，IC₅₀ 为 0.5 μM。P053 作为肌肉线粒体脂肪酸氧化的内源性抑制剂。全身肥胖调节剂。

生物活性

P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC₅₀ of 0.5 μM. P053 acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle. Whole-body adiposity regulator.

体外研究

P053 is the first isoform-specific ceramide synthase inhibitor. P053 inhibits CerS1 with nanomolar potency. P053 inhibits different human (h) or murine (m) CerS isoforms hCerS1, mCerS1, hCerS2, mCerS2, hCerS4, mCerS5, and hCerS6 with IC₅₀s of 0.54±0.06, 0.46±0.08, 28.6±0.15, 18.5±0.12, 17.2±0.09, 7.2±0.10, and 11.4±0.17 μM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

P053 (5 mg/kg; administered daily by oral gavage; 7 days, in male C57BL6/J mice ) reduces C18 ceramide levels in skeletal muscle (SkM) .
Daily P053 administration to mice fed a high-fat diet (HFD) increases fatty acid oxidation in skeletal muscle and impedes increases in muscle triglycerides and adiposity, but does not protect against HFD-induced insulin resistance.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL6/J mice
Dosage:	5 mg/kg
Administration:	Oral gavage; daily
Result:	Reduced C18 ceramide levels in SkM by 31%, whereas 1 mg/kg/day had no effect.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL6/J mice
Dosage:	5 mg/kg
Administration:	Oral gavage; daily
Result:	Reduced C18 ceramide levels in SkM by 31%, whereas 1 mg/kg/day had no effect.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (282.27 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8227 mL	14.1135 mL	28.2271 mL
5 mM	0.5645 mL	2.8227 mL	5.6454 mL
10 mM	0.2823 mL	1.4114 mL	2.8227 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式