L-Phenylalanine-d<sub>8</sub> (S-2-Amino-3-phenylpropionic acid-d<sub>8</sub>)|cas:17942-32-4|西域试剂

L-Phenylalanine-d₈ (S-2-Amino-3-phenylpropionic acid-d₈),99.96%

产品编号：Bellancom-N0215S1| CAS NO：17942-32-4| 分子式：C₉H₃D₈NO₂| 分子量：173.24

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-N0215S1	￥700.00	杭州北京（现货）
Bellancom-N0215S1	￥1900.00	杭州北京（现货）
Bellancom-N0215S1	￥3200.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

L-Phenylalanine-d₈ (S-2-Amino-3-phenylpropionic acid-d₈)

产品介绍

L-Phenylalanine-d₈ 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2⁺ 通道拮抗剂，K_i 为 980 nM。L-Phenylalanine 是 NMDARs (K_B 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。

生物活性

L-Phenylalanine-d₈ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[4].

体外研究

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

. Glushakov AV, et al. Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain. 2005 Feb;128(Pt 2):300-7. [Content Brief]

. Glushakov AV, et al. L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res. 2003 Apr 1;72(1):116-24. [Content Brief]

[4]. Glushakov AV, et al. Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry. 2002;7(4):359-67. [Content Brief]

[5]. Mortell KH, et al. Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. [Content Brief]

[6]. Wu WB, et al. Enhancement of l-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin. Biotechnol Appl Biochem. 2018 May;65(3):476-483. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

危险品运输编码	NONH for all modes of transport
WGK德国	3

上游产品 2
123052-95-9 123052-86-8
下游产品 0

L-Phenylalanine-d8 (S-2-Amino-3-phenylpropionic acid-d8),99.96%

L-Phenylalanine-d8 (S-2-Amino-3-phenylpropionic acid-d8)

化学品安全说明书(MSDS)

质检证书(COA)

在线咨询

L-Phenylalanine-d₈ (S-2-Amino-3-phenylpropionic acid-d₈),99.96%

L-Phenylalanine-d₈ (S-2-Amino-3-phenylpropionic acid-d₈)