(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12|cas:1797406-80-4|西域试剂

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12,99.67%

产品编号：Bellancom-103598| CAS NO：1797406-80-4| 分子式：C₃₀H₄₃N₇O₇S| 分子量：645.77

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货号	价格	库存与货期
Bellancom-103598	￥2200.00	杭州北京（现货）
Bellancom-103598	￥3100.00	杭州北京（现货）
Bellancom-103598	￥12000.00	杭州北京（现货）

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(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12

产品介绍

(S,R,S)-AHPC-PEG3-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。

生物活性

(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

体外研究

(S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Oil

溶解性数据

In Vitro:

Ethanol : 100 mg/mL (154.85 mM; Need ultrasonic)

H₂O : ≥ 100 mg/mL (154.85 mM)

DMSO : 50 mg/mL (77.43 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5485 mL	7.7427 mL	15.4854 mL
5 mM	0.3097 mL	1.5485 mL	3.0971 mL
10 mM	0.1549 mL	0.7743 mL	1.5485 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式