JTT 551|cas:776309-04-7|西域试剂

JTT 551,99.17%

产品编号：Bellancom-19779| CAS NO：776309-04-7| 分子式：C₃₄H₄₃N₃O₃S₂| 分子量：605.85

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-19779		￥6200.00	杭州北京（现货）
Bellancom-19779		￥9800.00	杭州北京（现货）

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JTT 551

产品介绍

JTT 551 是一种选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，K_i 值为 0.22 μM，同时对 T 细胞蛋白酪氨酸磷酸酶 (TCPTP）也有作用，K_i 值为 9.3 μM，可用于二型糖尿病的研究。

生物活性

JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

体外研究

JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with K_is of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (165.06 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6506 mL	8.2529 mL	16.5057 mL
5 mM	0.3301 mL	1.6506 mL	3.3011 mL
10 mM	0.1651 mL	0.8253 mL	1.6506 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献