Tenovin-6 Hydrochloride|cas:1011301-29-3|西域试剂

Tenovin-6 Hydrochloride,98.0%

产品编号：Bellancom-15510B| CAS NO：1011301-29-3| 分子式：C₂₅H₃₅ClN₄O₂S| 分子量：491.09

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货号	价格	库存与货期
Bellancom-15510B	￥990.00	杭州北京（现货）
Bellancom-15510B	￥2300.00	杭州北京（现货）
Bellancom-15510B	￥3600.00	杭州北京（现货）
Bellancom-15510B	￥9900.00	杭州北京（现货）
Bellancom-15510B	￥0.00	杭州北京（现货）

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Tenovin-6 Hydrochloride

产品介绍

Tenovin-6 Hydrochloride 是 Tenovin-1 (HY-13423) 的类似物，是一种 p53 转录活性的激活剂。Tenovin-6 Hydrochloride 抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC₅₀ 分别为 21 μM、10 μM 和 67 μM。Tenovin-6 Hydrochloride 也能抑制二氢乳清酸脱氢酶 (DHODH)。

生物活性

Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH).

体外研究

Tenovin-6 Hydrochloride inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1. Tenovin-6 Hydrochloride rapidly increases the levels of endogenous K382-Ac p53 in MCF-7 cells.
Tenovin-6 Hydrochloride (0 to 15 μM) dose dependently increases the level of LC3-II in diverse cell types, and the increase is ATG5/7 dependent. Tenovin-6 Hydrochloride treatment also increases the number and intensity of autophagic vesicles with or without the presence of Torin 1, and prevents Torin 1-induced SQSTM1/p62 degradation. Tenovin-6 Hydrochloride affects the acidification of autolysosomes and impairs the hydrolytic activity of lysosomes but does not affect the fusion between autophagosomes and lysosomes. That Tenovin-6 Hydrochloride inhibits autophagy does not correlate with p53 activation and SIRT1/2 inhibition by knockdown or knockout cannot mimic the effect of Tenovin-6 Hydrochloride on LC3B accumulation.
Tenovin-6 Hydrochloride (0, 1, 2.5, 5 or 10 μM) potently inhibits cell proliferation in a dose- and time-dependent manner in all OCI-Ly1, DHL-10, U2932, RIVA, HBL1 and OCI-Ly10 cell lines. Tenovin-6 Hydrochloride consistently increases LC3B-II level in DLBCL cell lines by inhibiting the classical autophagy pathway, without activating p53, and the increase is independent of SIRT1/2/3 and p53. Tenovin-6 Hydrochloride induces apoptosis through the extrinsic cell-death pathway^[4.
Tenovin-6 Hydrochloride suppresses the growth of UM cells with IC50 of 12.8 μM, 11.0 μM, 14.58 μM and 9.62 μM for 92.1, Mel 270, Omm 1 and Omm 2.3 cells, respectively^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tenovin-6 Hydrochloride (50 mg/kg, i.p.) inhibits the growth of tumor in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tenovin-6 Hydrochloride (50 mg/kg, i.p.) inhibits the growth of tumor in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 49 mg/mL (99.78 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0363 mL	10.1814 mL	20.3629 mL
5 mM	0.4073 mL	2.0363 mL	4.0726 mL
10 mM	0.2036 mL	1.0181 mL	2.0363 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献