SBI-993|cas:2073059-82-0|西域试剂

SBI-993,98.67%

产品编号：Bellancom-122682| CAS NO：2073059-82-0| 分子式：C₂₃H₂₄N₄O₄S| 分子量：452.53

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-122682	￥2250.00	杭州北京（现货）
Bellancom-122682	￥3780.00	杭州北京（现货）
Bellancom-122682	￥8280.00	杭州北京（现货）
Bellancom-122682	￥13500.00	杭州北京（现货）

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SBI-993

产品介绍

SBI-993 是一种 SBI-477 类似物，具有改进的效力和适合体内生物利用度的药代动力学特性。SBI-993 通过使转录因子 MondoA 失活来刺激胰岛素信号传导。

生物活性

SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA.

体外研究

SBI-993 reduces thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) expression in human myotubes.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SBI-993 (50 mg/kg; s.c.; daily; for 7 days) treatment reduces the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver. SBI-993 also reduces Txnip and Arrdc4 expression. And ccupation of both ChREBP and MondoA on the Txnip and pyruvate kinase (Pklr) gene promoters is reduced in liver by SBI-993.
SBI-993 improves insulin signaling in both muscle and liver following an acute insulin challenge.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice are fed a 60% high-fat diet (HFD)
Dosage:	50 mg/kg
Administration:	s.c.; daily; for 7 days
Result:	Reduced the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice are fed a 60% high-fat diet (HFD)
Dosage:	50 mg/kg
Administration:	s.c.; daily; for 7 days
Result:	Reduced the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (220.98 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2098 mL	11.0490 mL	22.0980 mL
5 mM	0.4420 mL	2.2098 mL	4.4196 mL
10 mM	0.2210 mL	1.1049 mL	2.2098 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献