BPH-652|cas:157124-84-0|西域试剂

BPH-652,98.61%

产品编号：Bellancom-16115| CAS NO：157124-84-0| 分子式：C₁₆H₁₆K₃O₇PS| 分子量：500.63

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-16115		￥8500.00	杭州北京（现货）
Bellancom-16115		￥13000.00	杭州北京（现货）

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BPH-652

产品介绍

BPH-652 是 CrtM 的抑制剂，K_i 值为 1.5 nM，IC₅₀ 值为100-300 nM (S. aureus 色素形成)。

生物活性

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a K_i of 1.5 nM and an IC₅₀ of 100-300 nM (S. aureus pigment formation).

体外研究

体内研究

BPH-652 treatment (0.5 mg twice per day (days −1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A systemic S. aureus infection model in mice.
Dosage:	0.5 mg twice per day (days −1, 0, 1, and 2).
Administration:	Intraperitoneal injection.
Result:	S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A systemic S. aureus infection model in mice.
Dosage:	0.5 mg twice per day (days −1, 0, 1, and 2).
Administration:	Intraperitoneal injection.
Result:	S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group.

性状

Solid

溶解性数据

In Vitro:

H₂O : 25 mg/mL (49.94 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9975 mL	9.9874 mL	19.9748 mL
5 mM	0.3995 mL	1.9975 mL	3.9950 mL
10 mM	0.1997 mL	0.9987 mL	1.9975 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献