Implitapide 英普他派; AEGR 427|cas:177469-96-4|西域试剂

Implitapide 英普他派; AEGR 427,99.87%

产品编号：Bellancom-106130| CAS NO：177469-96-4| 分子式：C₃₅H₃₇N₃O₂| 分子量：531.69

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-106130		￥7760.00	杭州北京（现货）
Bellancom-106130		￥12500.00	杭州北京（现货）

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Implitapide 英普他派; AEGR 427

产品介绍

Implitapide (AEGR 427) 是一种微粒体甘油三酯转移蛋白 (MTP) 抑制剂。

生物活性

Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.

体外研究

Implitapide suppresses MTP activity using a recombinant human form complexed with protein disulphide isomerase (IC₅₀=10 nM) and inhibit secretion of apoB-containing very low-density lipoprotein (VLDL)-like lipoproteins from a human hepatoma cell (HepG2) with an IC₅₀ value of 1.1 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Implitapide (3.2 mg/kg/d) significantly reduces the plasma lipid levels to nearly or below the chow diet (CD) level at 4 and 8 weeks of treatment (p<0.01). Implitapide (3.2 mg/kg/d) markedly suppresses lipid-stained lesions in the mice fed the western-type diet (WD). Implitapide (3.2 mg/kg/d) significantly decreases lesion area by 83% compared with that of the WD group (p<0.01). ApoE KO mice fed a WD containing Implitapide (1, 5, and 15 mg/kg/d) for 14 weeks have been shown to reduce significantly both plaque area (by 66, 78, and 93%, respectively) and lipid moieties within plaque (4.3, 2.6, and 0%, respectively, versus 9.5% in controls). Implitapide at a dosage of approximately 3.2 mg/kg/d significantly reduces the lipid-stained aortic lesions by 83% in apoE KO mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (188.08 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8808 mL	9.4040 mL	18.8080 mL
5 mM	0.3762 mL	1.8808 mL	3.7616 mL
10 mM	0.1881 mL	0.9404 mL	1.8808 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.70 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.70 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。