TUG-469|cas:1236109-67-3|西域试剂

TUG-469,99.90%

产品编号：Bellancom-123297| CAS NO：1236109-67-3| 分子式：C₂₃H₂₃NO₂| 分子量：345.43

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货号	价格	库存与货期
Bellancom-123297	￥500.00	杭州北京（现货）
Bellancom-123297	￥800.00	杭州北京（现货）
Bellancom-123297	￥1500.00	杭州北京（现货）
Bellancom-123297	￥2500.00	杭州北京（现货）
Bellancom-123297	￥4000.00	杭州北京（现货）

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TUG-469

产品介绍

TUG-469 是选择性的游离脂肪酸受体 1 (FFA1/GPR40) 激动剂，EC₅₀ 值为 19 nM。TUG-469 对 FFA1 的选择性是 FFA4 的 200 倍。TUG-469 显著改善糖尿病早期小鼠的糖耐量。TUG-469 可用于糖尿病的研究。

生物活性

TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC₅₀ value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.

体外研究

TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC₅₀ value of 7.73.
TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation.
TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC₅₀ values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively.
TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NZO mice with glucose administration
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration
Result:	Reduced the blood glucose level.

体内研究

TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NZO mice with glucose administration
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration
Result:	Reduced the blood glucose level.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (289.49 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8949 mL	14.4747 mL	28.9494 mL
5 mM	0.5790 mL	2.8949 mL	5.7899 mL
10 mM	0.2895 mL	1.4475 mL	2.8949 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式