Androgen receptor antagonist 2|cas:1272719-00-2|西域试剂

Androgen receptor antagonist 2,99.03%

产品编号：Bellancom-145451| CAS NO：1272719-00-2| 分子式：C₂₁H₁₅F₅N₄O₂S| 分子量：482.43

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-145451	￥2500.00	杭州北京（现货）
Bellancom-145451	￥3800.00	杭州北京（现货）
Bellancom-145451	￥7500.00	杭州北京（现货）
Bellancom-145451	￥12000.00	杭州北京（现货）

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Androgen receptor antagonist 2

产品介绍

Androgen receptor antagonist 2 (example 12) 是一种雄激素受体（androgen receptor）拮抗剂。Androgen receptor antagonist 2 可用于前列腺癌和男性脱发的研究。

生物活性

Androgen receptor antagonist 2 (example 12) is an androgen receptor antagonist. Androgen receptor antagonist 2 can be used for prostate cancer and male hair loss research.

体外研究

Androgen receptor antagonist 2 (example 12) inhibits PSA production with an IC₅₀ of 0.28 μM in LNCaP cells.
Androgen receptor antagonist 2 (2.5 μM, 48 h) inhibits prostate cancer cells viability.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	LNCaP and 22RV1 cells
Concentration:	2.5 μM
Incubation Time:	48 h
Result:	Inhibited cell viability with inhibition rates of 86% and 61% for LNCaP and 22RV1 cells, respectively.

体内研究
(In Vivo)

Androgen receptor antagonist 2 (example 12) (0.2% and 1% concentration, 20 mL/mouse; topical application; twice daily for 4 weeks) promotes hair growth in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-to 8-wk-old male C57BL/6 mice in the telogen stage of the hair cycle, weighing 15-20 g
Dosage:	0.2% and 1% concentration, 20 mL/mouse (0.04 and 0.2 mg/mouse)
Administration:	Topical application, twice daily for 4 weeks
Result:	Stimulated hair growth in dose dependent patterns.

体内研究

Androgen receptor antagonist 2 (example 12) (0.2% and 1% concentration, 20 mL/mouse; topical application; twice daily for 4 weeks) promotes hair growth in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-to 8-wk-old male C57BL/6 mice in the telogen stage of the hair cycle, weighing 15-20 g
Dosage:	0.2% and 1% concentration, 20 mL/mouse (0.04 and 0.2 mg/mouse)
Administration:	Topical application, twice daily for 4 weeks
Result:	Stimulated hair growth in dose dependent patterns.

体内研究

Androgen receptor antagonist 2 (example 12) (0.2% and 1% concentration, 20 mL/mouse; topical application; twice daily for 4 weeks) promotes hair growth in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-to 8-wk-old male C57BL/6 mice in the telogen stage of the hair cycle, weighing 15-20 g
Dosage:	0.2% and 1% concentration, 20 mL/mouse (0.04 and 0.2 mg/mouse)
Administration:	Topical application, twice daily for 4 weeks
Result:	Stimulated hair growth in dose dependent patterns.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (518.21 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0728 mL	10.3642 mL	20.7284 mL
5 mM	0.4146 mL	2.0728 mL	4.1457 mL
10 mM	0.2073 mL	1.0364 mL	2.0728 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.31 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.31 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。