Galegine hydrochloride|cas:2368870-39-5|西域试剂

Galegine hydrochloride,97.0%

产品编号：Bellancom-N0930B| CAS NO：2368870-39-5| 分子式：C₆H₁₄ClN₃| 分子量：163.65

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N0930B		￥1600.00	杭州北京（现货）
Bellancom-N0930B		￥2800.00	杭州北京（现货）

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Galegine hydrochloride

产品介绍

Galegine hydrochloride, 一种胍衍生物，有助于小鼠减轻体重。胍类是从 G. officinalis 中提取的化合物，产生双胍、二甲双胍和苯甲双胍。Galegine hydrochloride 激活 3T3-L1 脂肪细胞、L6 肌管、H4IIE 大鼠肝癌和 HEK293 人肾细胞系中的 AMPK。Galegine hydrochloride 具有抗菌活性，对金黄色葡萄球菌菌株 (Staphylococcus aureus) 的最低抑菌浓度为 4 mg/L。

生物活性

Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.

体外研究

Pre-treatment with Galegine hydrochloride (10 μM-3 mM; 5 h) produces a concentration-dependent stimulation of insulin-independent glucose uptake by 3T3-L1 adipocytes without any effect on cell viability. Incubation with Galegine hydrochloride (1 μM-1 mM, 5 h) produces a concentration-dependent stimulation of glucose uptake into L6 myotubes, again without any effect on cell viability.
Galegine hydrochloride (0.3-300 μM; 24 hours) produced a slight reduction in basal glycerol release and a more marked reduction in isoprenaline-stimulated glycerol release from 3T3-L1 adipocytes. Incubation of H4IIE rat hepatoma cells with Galegine hydrochloride (10 or 300 μM) for up to 6 hours produces a time-dependent activation of AMPK measured in cell lysates, with maximal activation at 360 min and twofold activation still evident at 24 hous in the presence of 300 μM Galegine hydrochloride. The effect of 300 ΜM Galegine hydrochloride is markedly greater than that of 10 μM. Incubation with Galegine hydrochloride for 1 hour produces a concentration-dependent activation of AMPK in both 3T3L-1 adipocytes and L-6 myotubes. Galegine hydrochloride also produces a concentration-dependent activation of the enzyme in a human kidney cell line (HEK293).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) produces a significant reduction in body weight.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male BALB/c mice
Dosage:	63 mg/kg
Administration:	feed; daily for 11 days
Result:	Produced a significant reduction in body weight.

体内研究

Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) produces a significant reduction in body weight.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male BALB/c mice
Dosage:	63 mg/kg
Administration:	feed; daily for 11 days
Result:	Produced a significant reduction in body weight.

性状

Solid

溶解性数据

In Vitro:

H₂O : 43.33 mg/mL (264.77 mM; Need ultrasonic)

DMSO : 5.2 mg/mL (31.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.1106 mL	30.5530 mL	61.1060 mL
5 mM	1.2221 mL	6.1106 mL	12.2212 mL
10 mM	0.6111 mL	3.0553 mL	6.1106 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献