GW-803430 GW-3430|cas:515141-51-2|西域试剂

GW-803430 GW-3430,98.06%

产品编号：Bellancom-11083| CAS NO：515141-51-2| 分子式：C₂₅H₂₄ClN₃O₃S| 分子量：481.99

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-11083		￥4500.00	杭州北京（现货）
Bellancom-11083		￥7500.00	杭州北京（现货）

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GW-803430 GW-3430

产品介绍

GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC₅₀ 为 9.3。GW-803430 在肥胖动物模型中具有口服活性。

生物活性

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity.

体外研究

GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC₅₀ value of ~13 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t_1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High fat diet-induced obese AKR/J mice
Dosage:	0.3, 3, and 15 mg/kg
Administration:	Orally, qd,12 days
Result:	Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High fat diet-induced obese AKR/J mice
Dosage:	0.3, 3, and 15 mg/kg
Administration:	Orally, qd,12 days
Result:	Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.