Melinamide 甲亚油酰胺; AC 223; DL-N-(α-Methylbenzyllinoleamide)|cas:14417-88-0|西域试剂

Melinamide 甲亚油酰胺; AC 223; DL-N-(α-Methylbenzyllinoleamide),99.94%

产品编号：Bellancom-101722| CAS NO：14417-88-0| 分子式：C₂₆H₄₁NO| 分子量：383.61

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货号	价格	库存与货期
Bellancom-101722	￥2000.00	杭州北京（现货）
Bellancom-101722	￥3500.00	杭州北京（现货）
Bellancom-101722	￥6000.00	杭州北京（现货）
Bellancom-101722	￥8500.00	杭州北京（现货）
Bellancom-101722	￥11500.00	杭州北京（现货）

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Melinamide 甲亚油酰胺; AC 223; DL-N-(α-Methylbenzyllinoleamide)

产品介绍

Melinamide是不饱和长链脂肪酸的酰胺衍生物。它是胆固醇吸收的抑制剂，IC₅₀值为20.9 μM。

生物活性

Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC₅₀ of 20.9 μM.

体外研究

DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Oil

溶解性数据

In Vitro:

DMSO : 200 mg/mL (521.36 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6068 mL	13.0341 mL	26.0681 mL
5 mM	0.5214 mL	2.6068 mL	5.2136 mL
10 mM	0.2607 mL	1.3034 mL	2.6068 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式