Risarestat CT 112|cas:79714-31-1|西域试剂

Risarestat CT 112,98.09%

产品编号：Bellancom-16433| CAS NO：79714-31-1| 分子式：C₁₆H₂₁NO₄S| 分子量：323.41

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货号	价格	库存与货期
Bellancom-16433	￥5000.00	杭州北京（现货）
Bellancom-16433	￥8500.00	杭州北京（现货）
Bellancom-16433	￥18000.00	杭州北京（现货）
Bellancom-16433	￥30000.00	杭州北京（现货）
Bellancom-16433	￥46000.00	杭州北京（现货）

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Risarestat CT 112

产品介绍

Risarestat (CT-112)是一种醛糖还原酶抑制剂，开发用于糖尿病并发症的研究。

生物活性

Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

体外研究

体内研究

Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution. Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns². Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm². Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 105 mg/mL (324.67 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0921 mL	15.4603 mL	30.9205 mL
5 mM	0.6184 mL	3.0921 mL	6.1841 mL
10 mM	0.3092 mL	1.5460 mL	3.0921 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 5.25 mg/mL (16.23 mM); Clear solution

此方案可获得 ≥ 5.25 mg/mL (16.23 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 52.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。