RMC-6272 RM-006|cas:2382769-46-0|西域试剂

RMC-6272 RM-006,95.54%

产品编号：Bellancom-134904| CAS NO：2382769-46-0| 分子式：C₉₅H₁₄₁FN₆O₂₇S| 分子量：1850.22

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-134904		￥11500.00	杭州北京（现货）

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RMC-6272 RM-006

产品介绍

RMC-6272 (RM-006) 是一种双空间的，选择性的 mTORC1 抑制剂，对 mTORC1 的抑制作用比 mTORC2 强且选择性 >10 倍。与雷帕霉素相比，RMC-6272 对 mTORC1 的抑制作用增强，并在 TSC2 阴性肿瘤中诱导更多的细胞死亡。

生物活性

RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors.

体外研究

RMC-6272 shows more effective growth inhibition in multiple TSC1 or TSC2 mutant tumor cell lines compared to Rapamycin. RMC-6272 causes a more profound growth inhibition in the TSC1 or TSC2 mutant cells than the wild type cells. RMC-6272 at ~1 nM shows near complete inhibition of p4E-BP1^T37/46, while inhibition of pS6^S240/244 levels is similar for Rapamycin and RM compounds.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

RMC-6272 markedly reduces kidney tumor burden in Tsc2^+/- A/J mice after four weeks of treatment. Tumor regrowth is assessed two months after treatment cessation, tumor burden is significantly reduced in the RMC-6272 group as compared to the Rapamycin and MLN0128 groups.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (13.51 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.5405 mL	2.7024 mL	5.4048 mL
5 mM	0.1081 mL	0.5405 mL	1.0810 mL
10 mM	0.0540 mL	0.2702 mL	0.5405 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式