Niraparib (R-enantiomer) MK 4827 (R-enantiomer)|cas:1038915-58-0|西域试剂

Niraparib (R-enantiomer) MK 4827 (R-enantiomer),99.69%

产品编号：Bellancom-10619D| CAS NO：1038915-58-0| 分子式：C₁₉H₂₀N₄O| 分子量：320.39

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货号	价格	库存与货期
Bellancom-10619D	￥1200.00	杭州北京（现货）
Bellancom-10619D	￥2200.00	杭州北京（现货）
Bellancom-10619D	￥3800.00	杭州北京（现货）
Bellancom-10619D	￥9900.00	杭州北京（现货）

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Niraparib (R-enantiomer) MK 4827 (R-enantiomer)

产品介绍

Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种高效的 PARP1 抑制剂，IC₅₀ 为 2.4 nM。

生物活性

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC₅₀ of 2.4 nM.

体外研究

Niraparib R-enantiomer (MK-4827 R-enantiomer) resolution of Niraparib R-enantiomer give compounds Niraparib R-enantiomer and Niraparib S-enantiomer, both showing excellent inhibition of PARP-1. Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC₅₀, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC₅₀, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Cl_int, Niraparib R-enantiomer=4, Niraparib S-enantiomer=3 μL/min/mgP), Niraparib S-enantiomer (Niraparib) is focused on.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 32 mg/mL (99.88 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1212 mL	15.6060 mL	31.2120 mL
5 mM	0.6242 mL	3.1212 mL	6.2424 mL
10 mM	0.3121 mL	1.5606 mL	3.1212 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式