AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease.

AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.
AP-C5 potentiates cAMP signaling by PDE inhibition.
AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293(21):8173-8181.  [Content Brief]