FM19G11|cas:329932-55-0|西域试剂

FM19G11,98.35%

产品编号：Bellancom-15672| CAS NO：329932-55-0| 分子式：C₂₃H₁₇N₃O₈| 分子量：463.40

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货号	价格	库存与货期
Bellancom-15672	￥1280.00	杭州北京（现货）
Bellancom-15672	￥2200.00	杭州北京（现货）
Bellancom-15672	￥4800.00	杭州北京（现货）
Bellancom-15672	￥8200.00	杭州北京（现货）
Bellancom-15672	￥13000.00	杭州北京（现货）

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FM19G11

产品介绍

FM19G11 是一种 hypoxia-inducible factor-1-alpha (HIF-1α) 抑制剂，在 HeLa 细胞中抑制缺氧诱导的荧光素酶活性，其 IC₅₀ 值为 80 nM。当 HIF-1α 途径在常氧条件下失活时，FM19G11 会调节其他信号途径，包括 mTOR 和 PI3K/Akt/eNOS。

生物活性

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC₅₀ of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions.

体外研究

FM19G11 (30-300 nM) inhibits HIFα proteins in the HeLa cell lines.
FM19G11 (500 nM) promotes oligodendrocyte differentiation under hypoxia.
FM19G11 (300 nM; 3 days) suppresses the mRNA levels of O⁶-methylguanine DNA-methyltransferase (MGMT) significantly in hypoxic GBM‐XD, hypoxic T98G, and normoxic T98G cells.
M19G11 (300 nM; 3 days) significantly enhances the pro‐apoptotic effect of temozolomide (TMZ), although FM19G11 does not induce apoptosis by itself.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	GBM‐XD and T98G cells
Concentration:	300 nM
Incubation Time:	3 days
Result:	Had no cytotoxicity by itself. Enhanced the cytotoxicity of TMZ in hypoxic GBM-XD cells, hypoxic T98G cells, and normoxic T98G cells.

Western Blot Analysis

Cell Line:	GBM‐XD and T98G cells
Concentration:	300 nM
Incubation Time:	3 days
Result:	Suppressed MGMT expression significantly in both cell lines in hypoxic culture. Downregulated MGMT expression substantially inT98G cells in normoxic culture.

体内研究
(In Vivo)

FM19G11 ( intramedullary injection; 1-8 weeks) improves locomotion in severe spinal cord injury (SCI).
FM19G11 ( intramedullary injection; 8 weeks) induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes at the injury.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (215.80 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1580 mL	10.7898 mL	21.5796 mL
5 mM	0.4316 mL	2.1580 mL	4.3159 mL
10 mM	0.2158 mL	1.0790 mL	2.1580 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献