Leu-AMS|cas:288591-93-5|西域试剂

Leu-AMS,98.08%

产品编号：Bellancom-108900| CAS NO：288591-93-5| 分子式：C₁₆H₂₅N₇O₇S| 分子量：459.48

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货号	价格	库存与货期
Bellancom-108900	￥1900.00	杭州北京（现货）
Bellancom-108900	￥5900.00	杭州北京（现货）
Bellancom-108900	￥8900.00	杭州北京（现货）

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Leu-AMS

产品介绍

Leu-AMS (compound 6)，亮氨酸类似物，是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂，IC₅₀ 值为 22.34 nM，Leu-AMS 抑制了LRS 的催化活性，但不影响亮氨酸诱导的 mTORC1 活化。Leu-AMS在癌细胞和正常细胞中显示出细胞毒性，并抑制细菌的生长。

生物活性

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC₅₀ of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria.

体外研究

Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC₅₀ value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 49.17 mg/mL (107.01 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1764 mL	10.8819 mL	21.7637 mL
5 mM	0.4353 mL	2.1764 mL	4.3527 mL
10 mM	0.2176 mL	1.0882 mL	2.1764 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式