NRX-2663,98.20%
产品编号：Bellancom-141448| CAS NO：2763260-34-8| 分子式：C20H13F3N2O5| 分子量：418.32
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NRX-2663
| 产品介绍 | NRX-2663 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 β-catenin 与 β-TrCP 的结合，EC50 为 22.9 µM，Kd 为 54.8 nM。 | ||||||||||||
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| 生物活性 | NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM. | ||||||||||||
| 体外研究 |
NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
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| 性状 | Solid | ||||||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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