NDB|cas:1660153-08-1|西域试剂

NDB,98.94%

产品编号：Bellancom-138937| CAS NO：1660153-08-1| 分子式：C₂₆H₂₈Cl₂N₂O₂| 分子量：471.42

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-138937		￥1900.00	杭州北京（现货）
Bellancom-138937		￥5600.00	杭州北京（现货）

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NDB

产品介绍

NDB 是一种选择性人 FXRα (hFXRα) 拮抗剂，可有效调节 FXRα 下游基因的转录。NDB可用于抗糖尿病研究。

生物活性

NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research.

体外研究

NDB induces rearrangements of helix 11 (H11) and helix 12 (H12, AF-2) by forming a homodimer of hFXRα-LBD, totally different from the active conformation in monomer state.
NDB (25 μM) effectively antagonizes the GW4064-stimulated FXR/RXR interaction and FXRα target gene expression in primary mouse hepatocytes, including the small heterodimer partner (SHP) and bile-salt export pump (BSEP).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NDB (24 mg/kg; intraperitoneal injection; once a day; for 4 weeks) efficiently decreases the gene expressions of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6-pase), small heterodimer partner, and BSEP in db/db mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J db/db mice (8 weeks of age)
Dosage:	24 mg/kg
Administration:	Intraperitoneal injection; once a day; for 4 weeks
Result:	Decreased the gene expressions of PEPCK, G6-pase, small heterodimer partner, and BSEP.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J db/db mice (8 weeks of age)
Dosage:	24 mg/kg
Administration:	Intraperitoneal injection; once a day; for 4 weeks
Result:	Decreased the gene expressions of PEPCK, G6-pase, small heterodimer partner, and BSEP.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (212.13 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1213 mL	10.6063 mL	21.2125 mL
5 mM	0.4243 mL	2.1213 mL	4.2425 mL
10 mM	0.2121 mL	1.0606 mL	2.1213 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.30 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.30 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。