NTRC 0066-0|cas:1817791-73-3|西域试剂

NTRC 0066-0,98.90%

产品编号：Bellancom-100024| CAS NO：1817791-73-3| 分子式：C₃₃H₃₉N₇O₂| 分子量：565.71

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-100024	￥1800.00	杭州北京（现货）
Bellancom-100024	￥2900.00	杭州北京（现货）
Bellancom-100024	￥5800.00	杭州北京（现货）

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NTRC 0066-0

产品介绍

NTRC 0066-0 是一种选择性苏氨酸酪氨酸激酶 (TTK) 抑制剂 (IC₅₀=0.9 nM)。NTRC 0066-0可用于癌症研究。

生物活性

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer.

体外研究

NTRC 0066-0 has a low selectivity entropy and a relatively long target residence time on TTK and inhibits the proliferation of diverse cancer cell lines with a potency in the same range as that of classic chemotherapeutic agents such as doxorubicin. NTRC 0066-0, has subnanomolar potency in a TTK enzyme assay and inhibits the proliferation of cancer cell lines from diverse tumor tissue origin with IC₅₀ from 11 to 290 nM at 5-day incubation time.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 20.83 mg/mL (36.82 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7677 mL	8.8385 mL	17.6769 mL
5 mM	0.3535 mL	1.7677 mL	3.5354 mL
10 mM	0.1768 mL	0.8838 mL	1.7677 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式