680C91|cas:163239-22-3|西域试剂

680C91,98.16%

产品编号：Bellancom-108681| CAS NO：163239-22-3| 分子式：C₁₅H₁₁FN₂| 分子量：238.26

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货号	价格	库存与货期
Bellancom-108681	￥900.00	杭州北京（现货）
Bellancom-108681	￥1400.00	杭州北京（现货）
Bellancom-108681	￥3200.00	杭州北京（现货）
Bellancom-108681	￥4800.00	杭州北京（现货）

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680C91

产品介绍

680C91 是一种口服有效的，选择性色氨酸 2,3-双加氧酶 (TDO) 抑制剂，K_i 为 51 nM。TDO 是色氨酸分解代谢的关键酶。680C91 可用于肿瘤免疫和阿尔茨海默症的研究。

生物活性

680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a K_i of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease^[4].

体外研究

680C91 is a potent (K_i=51 nM) and selective TDO inhibitor with no inhibitory activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake and 5-HT1A,1D,2A and 2C receptors at a concentration of 10 μM.
680C91 inhibits the catabolism of tryptophan by rat liver cells and rat liver perfused in situ.
Tdo2 could regulate cell proliferation and stimulate the expression of decidual marker Dtprp in the uterine stromal cells and decidual cells. Tdo2 inhibitor 680C91 also inhibits the prolifer ation activity of uterine decidual cells at 24 h.
Treatment of leiomyoma smooth muscle cell (LSMC) and myometrial smooth muscle cell (MSMC) spheroids with 680C91 (25 and 50 μM) significantly represses the expression of collagen type I (COL1A1) and type III (COL3A1) in a dose-dependent manner^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Uterine stromal cells
Concentration:	0.01, 0.05, 0.1, 0.5, 1, 5, and 10 μM
Incubation Time:	24 hours
Result:	The proliferation activity of stromal cells was significantly decreased at 5 and 10 μM.

Western Blot Analysis^[4]

Cell Line:	MSMC and LSMC
Concentration:	25 and 50 μM
Incubation Time:	48 hours
Result:	Significantly reduced the expression of COL1A1 and COL3A1 in LSMC spheroids with no significant effect on expression of these proteins in MSMC spheroids.

体内研究
(In Vivo)

680C91 (a dose of 15 mg/kg for acute treatment ) elevates tryptophan in brain^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57Bl6/NCrl mice aged 13-18 weeks^[5]
Dosage:	15 mg/kg
Administration:	Administered per os
Result:	Caused a significant increase in brain tryptophan.

体内研究

680C91 (a dose of 15 mg/kg for acute treatment ) elevates tryptophan in brain^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57Bl6/NCrl mice aged 13-18 weeks^[5]
Dosage:	15 mg/kg
Administration:	Administered per os
Result:	Caused a significant increase in brain tryptophan.

体内研究

680C91 (a dose of 15 mg/kg for acute treatment ) elevates tryptophan in brain^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57Bl6/NCrl mice aged 13-18 weeks^[5]
Dosage:	15 mg/kg
Administration:	Administered per os
Result:	Caused a significant increase in brain tryptophan.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (524.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.1971 mL	20.9855 mL	41.9710 mL
5 mM	0.8394 mL	4.1971 mL	8.3942 mL
10 mM	0.4197 mL	2.0985 mL	4.1971 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式