C-176|cas:314054-00-7|西域试剂

C-176,99.45%

产品编号：Bellancom-112906| CAS NO：314054-00-7| 分子式：C₁₁H₇IN₂O₄| 分子量：358.09

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货号	价格	库存与货期
Bellancom-112906	￥1000.00	杭州北京（现货）
Bellancom-112906	￥1400.00	杭州北京（现货）
Bellancom-112906	￥2900.00	杭州北京（现货）
Bellancom-112906	￥4500.00	杭州北京（现货）

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C-176

产品介绍

C-176 是干扰素基因刺激受体 (STING) 的强效共价抑制剂。

生物活性

C-176 is a strong and covalent mouse STING inhibitor.

体外研究

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1^−/− mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1^−/− mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	WT type mice.
Dosage:	750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
Administration:	Intraperitoneally, once.
Result:	Significantly reduced Serum levels of type I IFNs and IL-6.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	WT type mice.
Dosage:	750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
Administration:	Intraperitoneally, once.
Result:	Significantly reduced Serum levels of type I IFNs and IL-6.

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (174.54 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7926 mL	13.9630 mL	27.9259 mL
5 mM	0.5585 mL	2.7926 mL	5.5852 mL
10 mM	0.2793 mL	1.3963 mL	2.7926 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： Cremophor EL
Solubility: 10 mg/mL (27.93 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: 1.67 mg/mL (4.66 mM); Suspended solution; Need ultrasonic and warming

此方案可获得 1.67 mg/mL (4.66 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液