UNBS5162|cas:956590-23-1|西域试剂

UNBS5162,98.10%

产品编号：Bellancom-16509| CAS NO：956590-23-1| 分子式：C₁₇H₁₈N₄O₃| 分子量：326.35

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货号	价格	库存与货期
Bellancom-16509	￥1500.00	杭州北京（现货）
Bellancom-16509	￥4500.00	杭州北京（现货）
Bellancom-16509	￥7500.00	杭州北京（现货）

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UNBS5162

产品介绍

UNBS5162 是一种广谱的趋化因子配体 CXCL 拮抗剂，具有抗肿瘤活性。

生物活性

UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

体外研究

UNBS5162 is a pan-antagonist of CXCL chemokine expression and exhibits weak antiproliferative activity against human cancer cell lines with mean IC₅₀ of 17.9 µM. UNBS5162 markedly impairs PC-3 tumor cell growth kinetics, without inducing senescence, whereas the reverse feature is observed with respect to DU-145 cells. UNBS5162 is cytotoxic to a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7), with IC₅₀s of 0.5-5 µM. UNBS5162 also markedly increases the levels of expression of LC3-I and LC3-II in human cancer cells. UNBS5162 displays no anti-topoisomerase II activity. Moreover, UNBS5162 induces cancer cell death through lysosomal membrane permeabilization (LMP) in PC3 prostate cancer cells but not in U373 glioblastoma cells, with this LMP process occurring as an UNBS5162-induced decrease in Hsp70 expression. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. UNBS5162 downregulates the protein expression of proteins associated with the PI3K/AKT signaling pathway, including the levels of phosphorylated (p)-AKT, p-mechanistic target of rapamycin kinase, ribosomal protein S6 kinase β1 and cyclin D1.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

UNBS5162 (20 mg/kg, i.v.) increases the therapeutic benefits of taxol in vivo in the orthotopic human PC-3 prostate cancer model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

UNBS5162 (20 mg/kg, i.v.) increases the therapeutic benefits of taxol in vivo in the orthotopic human PC-3 prostate cancer model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 21.5 mg/mL (65.88 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0642 mL	15.3210 mL	30.6419 mL
5 mM	0.6128 mL	3.0642 mL	6.1284 mL
10 mM	0.3064 mL	1.5321 mL	3.0642 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式