Semapimod tetrahydrochloride CNI-1493; CPSI-2364 tetrahydrochloride|cas:164301-51-3|西域试剂

Semapimod tetrahydrochloride CNI-1493; CPSI-2364 tetrahydrochloride,98.43%

产品编号：Bellancom-15509A| CAS NO：164301-51-3| 分子式：C₃₄H₅₆Cl₄N₁₈O₂| 分子量：890.74

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货号	价格	库存与货期
Bellancom-15509A	￥5500.00	杭州北京（现货）
Bellancom-15509A	￥8800.00	杭州北京（现货）
Bellancom-15509A	￥17600.00	杭州北京（现货）

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Semapimod tetrahydrochloride CNI-1493; CPSI-2364 tetrahydrochloride

产品介绍

Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC₅₀≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。

生物活性

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders.

体外研究

Semapimod tetrahydrochloride leads to a significant decrease of p38-MAPK phosphorylation in macrophages, proinflammatory gene expression of macrophage inflammatory protein-1alpha, interleukin-6, monocyte chemoattractant protein-1, and intercellular adhesion molecule-1, and neutrophil infiltration. Semapimod tetrahydrochloride completely abrogated nitric oxide production within the tunica muscularis.
Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96. Semapimod tetrahydrochloride inhibits ATP-binding and ATPase activities of gp96 in vitro (IC₅₀≈0.2-0.4 μM). Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Semapimod tetrahydrochloride (5 mg/kg; i.p; daily for 2 weeks) ameliorates endothelial dysfunction in Obese Zucker (OZ) rats.
Semapimod tetrahydrochloride restores AM-induced akt phosphorylation and cGMP production in OZ rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male OZ rats
Dosage:	5 mg/kg
Administration:	I.p; daily for 2 weeks
Result:	Restored endothelium-dependent vasorelaxation in OZ rats.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male OZ rats
Dosage:	5 mg/kg
Administration:	I.p; daily for 2 weeks
Result:	Restored endothelium-dependent vasorelaxation in OZ rats.

性状

Solid

溶解性数据

In Vitro:

H₂O : 2.17 mg/mL (2.44 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.1227 mL	5.6133 mL	11.2266 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献