7α,25-Dihydroxycholesterol 7α,25-OHC|cas:64907-22-8|西域试剂

7α,25-Dihydroxycholesterol 7α,25-OHC,98.05%

产品编号：Bellancom-113962| CAS NO：64907-22-8| 分子式：C₂₇H₄₆O₃| 分子量：418.65

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-113962		￥2250.00	杭州北京（现货）
Bellancom-113962		￥5500.00	杭州北京（现货）

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7α,25-Dihydroxycholesterol 7α,25-OHC

产品介绍

7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC₅₀=140 pM; K_d=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。

生物活性

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC₅₀=140 pM; K_d=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells.

体外研究

In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 4.55 mg/mL (10.87 mM; Need ultrasonic)

Ethanol : 1 mg/mL (2.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3886 mL	11.9432 mL	23.8863 mL
5 mM	0.4777 mL	2.3886 mL	4.7773 mL
10 mM	0.2389 mL	1.1943 mL	2.3886 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式