PPTN hydrochloride|cas:1992047-65-0|西域试剂

PPTN hydrochloride,99.89%

产品编号：Bellancom-110322| CAS NO：1992047-65-0| 分子式：C₂₉H₂₅ClF₃NO₂| 分子量：511.96

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货号	价格	库存与货期
Bellancom-110322	￥1200.00	杭州北京（现货）
Bellancom-110322	￥2000.00	杭州北京（现货）
Bellancom-110322	￥3900.00	杭州北京（现货）
Bellancom-110322	￥6000.00	杭州北京（现货）
Bellancom-110322	￥9000.00	杭州北京（现货）

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PPTN hydrochloride

产品介绍

PPTN hydrochloride 是一种有效，高亲和力，竞争性和高选择性的 P2Y14 受体拮抗剂，K_B 为 434 pM。PPTN hydrochloride 对 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和抗免疫活性。

生物活性

PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity.

体外研究

PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors.
PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC₅₀s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM.
PPTN (10 µM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (488.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9533 mL	9.7664 mL	19.5328 mL
5 mM	0.3907 mL	1.9533 mL	3.9066 mL
10 mM	0.1953 mL	0.9766 mL	1.9533 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献