DRI-C21045|cas:2101765-81-3|西域试剂

DRI-C21045,98.26%

产品编号：Bellancom-120323| CAS NO：2101765-81-3| 分子式：C₃₂H₂₄N₂O₇S| 分子量：580.61

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-120323	￥1250.00	杭州北京（现货）
Bellancom-120323	￥2000.00	杭州北京（现货）
Bellancom-120323	￥6000.00	杭州北京（现货）
Bellancom-120323	￥9800.00	杭州北京（现货）

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DRI-C21045

产品介绍

DRI-C21045 (compound 10) 是一种有效和选择性的 CD40-CD40L 共刺激蛋白-蛋白质相互作用 (PPI) 抑制剂，IC₅₀ 为 0.17 μM。DRI-C21045 显示对 CD40L 诱导的 NF-κB 活化和 B 细胞增殖的浓度依赖性抑制，IC₅₀ 分别为 17.1 μM 和 4.5 μM。

生物活性

DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC₅₀ of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC₅₀s of 17.1 µM and 4.5 µM, respectively.

体外研究

DRI-C21045 (3.2-100 μM; 18 h) concentration-dependently inhibits the CD40L-induced NF-κB activation in CD40 sensor cells.
DRI-C21045 (0.6-50 μM; 48 h) blocks CD40L-induced functional activation of primary B cells.
DRI-C21045 (0.4-50 μM; 48 h) inhibits CD40L-induced MHC-II upregulation in THP-1 cells.
DRI-C21045 (2-100 μM; 48 h) inhibits CD40L-induced B cell proliferation.
DRI-C21045 shows no signs of cytotoxicity for concentrations of up to 100 and 200 µM and has no genotoxic potential for concentrations of up to 500 µM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

DRI-C21045 (30 mg/kg; daily, s.c.; in 20% HPβCD) prolongs graft survival in a murine allogeneic skin transplant model.
DRI-C21045 (20-60 mg/kg; twice daily s.c.; in 20% HPβCD) inhibits alloantigen-induced T cell expansion in the draining lymph nodes (DLNs).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Full-thickness ear skins from BALB/c were transplanted onto the dorsal thorax of C57BL/6
Dosage:	30 mg/kg
Administration:	Daily s.c; administered in 20% w/v hydroxypropyl-β-cyclodextrin (HPβCD) solution
Result:	Caused prolongation of skin allograft survival.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Full-thickness ear skins from BALB/c were transplanted onto the dorsal thorax of C57BL/6
Dosage:	30 mg/kg
Administration:	Daily s.c; administered in 20% w/v hydroxypropyl-β-cyclodextrin (HPβCD) solution
Result:	Caused prolongation of skin allograft survival.

性状

Solid

溶解性数据

In Vitro:

DMSO : 2 mg/mL (3.44 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7223 mL	8.6116 mL	17.2233 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式