RIPK3-IN-1|cas:2361139-70-8|西域试剂

RIPK3-IN-1,98.82%

产品编号：Bellancom-131064| CAS NO：2361139-70-8| 分子式：C₂₉H₂₅FN₄O₄| 分子量：512.53

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货号	价格	库存与货期
Bellancom-131064	￥4000.00	杭州北京（现货）
Bellancom-131064	￥6800.00	杭州北京（现货）
Bellancom-131064	￥13500.00	杭州北京（现货）
Bellancom-131064	￥22000.00	杭州北京（现货）
Bellancom-131064	￥34000.00	杭州北京（现货）

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RIPK3-IN-1

产品介绍

RIPK3-IN-1 是 II 型 RIPK3 DFG-out 位点抑制剂，IC₅₀ 为 9.1 nM。RIPK3-IN-1 抑制 RIPK1 和 RIPK2，IC₅₀ 为 5.5 和 >10 μM。RIPK3-IN-1 还是 c-Met 激酶抑制剂，IC₅₀ 为 1.1 μM。

生物活性

RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC₅₀ of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC₅₀s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC₅₀ of 1.1 μM.

体外研究

RIPK3-IN-1 (Compound 18) also inhibits ABL, BRAF/V599E, MAP4K3, and SRC with IC₅₀s of 0.37, 0.15, 0.012, and 0.075 μM, respectively.
Necroptosis is a programmed form of cell death and has been associated with a variety of diseases, including ischemia reperfusion injury, neurodegenerative disorders, pancreatic cancer, and autoimmune diseases such as inflammatory bowel disease (IBD). Upon stimulation of death receptors (such as the family of TNF receptors), signaling can initiate a necroptotic cell death process. This involves formation of a necrosome, which includes receptor interacting protein kinases 1 and 3 (RIPK1, RIPK3) in a cytosolic complex.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (9.76 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9511 mL	9.7555 mL	19.5111 mL
5 mM	0.3902 mL	1.9511 mL	3.9022 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式