EL-102|cas:1233948-61-2|西域试剂

EL-102,99.76%

产品编号：Bellancom-16187| CAS NO：1233948-61-2| 分子式：C₁₉H₁₆N₂O₃S₂| 分子量：384.47

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-16187	￥1100.00	杭州北京（现货）
Bellancom-16187	￥2800.00	杭州北京（现货）
Bellancom-16187	￥4500.00	杭州北京（现货）
Bellancom-16187	￥9500.00	杭州北京（现货）
Bellancom-16187	￥15000.00	杭州北京（现货）

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EL-102

产品介绍

EL-102 是 hypoxia-induced factor 1 (Hif1α) 的抑制剂。EL-102 诱导细胞凋亡，抑制微管蛋白聚合，并显示抗前列腺癌活性。EL-102 可用于癌症的研究。

生物活性

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer.

体外研究

EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro.
EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines.
EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle.
EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells.
EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity.
EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration:	0-120 nM
Incubation Time:	72 hours
Result:	Inhibited proliferation of CWR22, 22Rv1, DU145, PC-3, DLKP and doxorubicin-selected variant DLKPA cells with IC₅₀s of 24, 21.7, 40.3, 37.0, 14.4 and 16.3 nM, respectively.

Cell Cytotoxicity Assay

Cell Line:	CWR22, 22Rv1, DU145 and PC-3 cell lines
Concentration:	0-100 nM
Incubation Time:	72 hours
Result:	Exibited cytotoxicity to prostate cancer cell lines, and showed no additive effect on the inhibition of cell viability with docetaxel.

Apoptosis Analysis

Cell Line:	CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration:	10 and 100 nM
Incubation Time:	24, 48 and 72 hours
Result:	Induced cell apoptosis to inhibits cell viability with a dose of 100 nM.

Western Blot Analysis

Cell Line:	DU145 cell line
Concentration:	10 and 100 nM
Incubation Time:	24 and 48 hours
Result:	Increased PARP cleavage in DU145 cells and showed a more dramatic effect with docetaxel adding.

Cell Cycle Analysis

Cell Line:	DU145 cell line
Concentration:	10 and 100 nM
Incubation Time:	24, 48 and 72 hours
Result:	Increased loss of cells from G1 phase and accumulated cells in G2/M phase.

Western Blot Analysis

Cell Line:	Prostate cancer cells
Concentration:	10 , 50 and 100 nM
Incubation Time:	24 and 48 hours
Result:	Modestly inhibited Hif1α expression at doses of 50 and 100 nM in normoxia.

体内研究
(In Vivo)

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with CWR22 xenografts
Dosage:	12 and 15 mg/kg
Administration:	Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result:	Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .

体内研究

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with CWR22 xenografts
Dosage:	12 and 15 mg/kg
Administration:	Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result:	Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .

体内研究

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with CWR22 xenografts
Dosage:	12 and 15 mg/kg
Administration:	Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result:	Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 36 mg/mL (93.64 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6010 mL	13.0049 mL	26.0098 mL
5 mM	0.5202 mL	2.6010 mL	5.2020 mL
10 mM	0.2601 mL	1.3005 mL	2.6010 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式