DDR1-IN-6|cas:2416021-47-9|西域试剂

DDR1-IN-6,98.16%

产品编号：Bellancom-133670| CAS NO：2416021-47-9| 分子式：C₂₃H₁₄F₃N₅O| 分子量：433.39

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货号	价格	库存与货期
Bellancom-133670	￥1800.00	杭州北京（现货）
Bellancom-133670	￥3150.00	杭州北京（现货）
Bellancom-133670	￥6300.00	杭州北京（现货）
Bellancom-133670	￥9900.00	杭州北京（现货）
Bellancom-133670	￥14850.00	杭州北京（现货）

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DDR1-IN-6

产品介绍

DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC₅₀ 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC₅₀ 为 9.7 nM。DDR1-IN-6 具有抗癌活性。

生物活性

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC₅₀ of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC₅₀ of 9.7 nM. DDR1-IN-6 has anti-cancer activity.

体外研究

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC₅₀=13 nM).
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC₅₀=3 μM).
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC₅₀=5.7 μM of 3 days; IC₅₀=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC₅₀>30 μM of 3 days; IC₅₀>30 μM of 6 days).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (23.07 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3074 mL	11.5370 mL	23.0739 mL
5 mM	0.4615 mL	2.3074 mL	4.6148 mL
10 mM	0.2307 mL	1.1537 mL	2.3074 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献