Syk Inhibitor II|cas:726695-51-8|西域试剂

Syk Inhibitor II,98.05%

产品编号：Bellancom-112390A| CAS NO：726695-51-8| 分子式：C₁₄H₁₅F₃N₆O| 分子量：340.30

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货号	价格	库存与货期
Bellancom-112390A	￥800.00	杭州北京（现货）
Bellancom-112390A	￥1500.00	杭州北京（现货）
Bellancom-112390A	￥4000.00	杭州北京（现货）
Bellancom-112390A	￥6400.00	杭州北京（现货）

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Syk Inhibitor II

产品介绍

Syk Inhibitor II 是一种有效的，高选择性和 ATP 竞争性 Syk 抑制剂，IC₅₀ 为 41 nM。Syk Inhibitor II 抑制 RBL 细胞释放 5-HT，IC₅₀ 为 460 nM。Syk Inhibitor II 对其他激酶的作用较小，并具有抗过敏作用。

生物活性

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect.

体外研究

Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC₅₀ values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID₅₀ value of 13.2 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (14.69 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9386 mL	14.6929 mL	29.3858 mL
5 mM	0.5877 mL	2.9386 mL	5.8772 mL
10 mM	0.2939 mL	1.4693 mL	2.9386 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式